D3k2 strong

Mechanisms of Action of Vitamins D3 and K2

Vitamin D3 (Cholecalciferol)
Vitamin D3 is a fat-soluble pro-hormone that regulates calcium and phosphorus metabolism, with crucial effects on:

• Intestinal calcium absorption: Promotes efficient active transport at the enteric level.

• Bone mineralization: Encourages mineral deposition in bone tissue.

• Blood pressure balance: Contributes to hemodynamic equilibrium through control of electrolyte absorption.
  A significant endogenous synthesis depends on UV exposure, but factors such as sedentary lifestyle and sunscreen use may compromise vitamin D3 levels, potentially leading to:

• Asthenia and muscle weakness

• Mood alterations, such as depression and irritability

• Increased risk of injuries and recurrent infections

Vitamin K2 (Menaquinone-7)
Vitamin K2 is essential for bone and cardiovascular metabolism, acting as a cofactor in activating proteins that regulate:

• Calcium deposition: Ensures transport into the bone matrix, preventing pathological calcification of arteries and soft tissues.

• Bone mineral density: Strengthens skeletal structure, reducing the risk of osteoporosis.
  The combination with vitamin D3 amplifies the effects of both, improving overall efficacy in conditions related to calcium metabolism.

Immune Role of Vitamin D3

Vitamin D3 exerts systemic modulation on both innate and adaptive immunity. Its actions include:

• Activation of T-lymphocytes: Stimulates differentiation and activity of specialized immune cells such as macrophages and helper T cells.

• Anti-inflammatory Properties: Reduces production of pro-inflammatory cytokines, contributing to prevention of autoimmune and chronic inflammatory conditions.

Clinical Indications for D3 and K2 Strong

The use of D3 and K2 Strong is particularly indicated in conditions such as:

• Vitamin D3 and/or K2 deficiency, detectable through functional deficits or blood tests

• Muscle weakness and general fatigue, often associated with low cholecalciferol levels

• Osteoporosis and skeletal fragility in adults and rickets in children

• Reduced immune defenses and increased susceptibility to chronic or recurrent infections

• Prevention of vascular calcification in patients with elevated cardiovascular risk

Directions for Use and Warnings

• Recommended intake: 1 capsule per day, preferably during meals to maximize absorption of the liposoluble nutrients.

• Warnings: Do not exceed the recommended daily dose. Use is contraindicated without medical supervision in case of pregnancy, breastfeeding, or pre-existing medical conditions.